"If we are to understand dynamics of bacterial-host cell interactions, we need to investigate the intimate adaptations at the cellular and molecular levels"
Welcome to my personal website. I am a research scientist at CIRAD in the Caribbean Research Centre for Vector-borne diseases (approx. 20 people). We are located on the INRA campus in Petit-Bourg, Guadeloupe and we are part of the ASTRE research unit based in Montpellier. I have worked on numerous whole genome sequencing projects and functional genomics projects for Xanthomonas campestris pv. campestris, X. c. pv. raphani, X. oryzae pv. oryzae, X. o. pv. oryzicola and Ehrlichia ruminantium. My current research interests are directed toward understanding the biology host-intracellular bacteria interactions.
Bacterial pathogens and symbionts exploit a wide array of strategies to facilitate interaction with hosts. For endosymbiotic or intracellular pathogenic bacteria, there is a constant need to manipulate signaling pathways in the eukaryotic mammalian or arthropod host cell. I am particularly interested in the pathways used by intracellular pathogenic Ehrlichia bacteria to enter host cells and create a safe replicating niche. I am also investigating how endosymbiotic Wolbachia bacteria interact with eukaryotic cells. My research encompasses the underlying molecular mechanisms of these processes and the illumination of how these strategies facilitate unique interactions with the host immune system, most notably for immune evasion.
To this aim, I use a systems biology approach that goes from molecular and cellular biology to translational studies with particular emphasis on the interface between the bacterium and its host (vertebrate and invertebrate ; unicellular or multicellular). The unifying theme is the integrated study of infectious strategies of Anaplasmataceae (pathogenic Ehrlichia and symbiotic Wolbachia) in conjunction and communication with each other, their host, and the cellular environment they inhabit.
Findings from this work contribute to understanding the mechanisms of pathogenesis and endosymbiosis as well as advancement of human and animal health interests.
This site contains a more detailed description of my research projects at CIRAD, an introduction to people working with me, reprints of all of my publications, and other useful links.
Infectious Strategies of Anaplasmataceae
My research focus is on how the obligate tick-borne intracellular pathogen Ehrlichia ruminantium (Anaplasmataceae family) manipulates cellular function in order to multiply inside host cells and cause infectious disease.
Heartwater disease caused by E. ruminantium is generally fatal on ruminants and is common in sub-Saharan Africa and in some Caribbean islands. Some human cases have been reported in South Africa. The clinical signs of heartwater (also known as cowdriosis) are caused by an increased vascular permeability and consequent œdema. The symptoms include neurological signs (tremors), respiratory signs (coughing) and systemic signs (fever, loss of appetite).
In the host, E. ruminantium infects endothelial cells and neutrophils, where the pathogen replicates to high numbers in an intracellular vacuole. Ehrlichia produces a Type IV Secretion System (T4SS) to deliver proteins into the host cytoplasm where they can manipulate the host cell machinery and subvert host innate immunity. However, due to a lack of methods for genetic manipulation of the bacterium, Ehrlichia virulence factors remain largely unknown.
Using bioinformatics, genomics, proteomics, cellular and molecular biology approaches, we aim to identify E. ruminantium T4SS substrates and their host targets.
The three major points I am particularly interested in are :
Our studies will provide information about the molecular arsenal used by E. ruminantium and other Anaplasmataceae for successful development inside its host cell. We are also studying the impact of these bacteria on host cells signaling.
Altogether, our research will give new insights on the intimate interaction of Anaplasmataceae with their mammalian or tick host cells and will foster the development of new anti-bacterial molecules.
Entry of E. ruminantium into host cells
Intracellular pathogens have evolved numerous strategies for promoting their entry into host cells, consistent with its essential role in pathogenesis. Yet despite its fundamental importance, Ehrlichial entry remains a largely unexplored research area.
Using microscopy and proteomics, we are characterizing outer membrane proteins involved in E. ruminantium early attachment to host cell and decoy of innate immunity.
Pseudo-colored scanning electron micrograph of E. ruminantium attaching to the surface of BAE cells ultimately leading to bacterial invasion.
Molecular mechanisms to manipulate host processes
We are investigating the role of the Type IV Secretion System of E. ruminantium in bacterial adaptation to the host cell. We want to know how it is expressed along developmental cycle of E. ruminantium between strains of various virulence.
We developed S4TE, a bioinformatic tool in Perl to predict Type IV Secreted Effector proteins of E. ruminantium and to analyse their genomic context. Using molecular and cell biology tools, we are characterizing the function of these effectors.
Inside-out lysis of the host cell by the pathogen
E. ruminantium is also capable of escaping host cells by lysis of its resident vacuole and host plasma membranes, followed by subsequent release of free bacteria into the extracellular compartment. For obligate intracellular pathogens, lysis is a biological process that is tightly regulated. We are using functional genomics and cellular biology to identify key players and signaling pathways involved in this process.
I have additional interests in the broader arenas of microbial pathogenesis. Research topics of particular interest to me are :
Who we are…
Damien F. Meyer
Microbial Genomics | End User eXperience
Group "Infectious strategies of Anaplasmataceae"
Head of the Biological Resource Center for Microbes and Vectors in the Caribbean
CIRAD, UMR ASTRE
Ph.D., Univ. Paul Sabatier, Toulouse, FR
M.Sc., Univ. Paul Sabatier, Toulouse, FR
B.Sc., Univ. Blaise Pascal, Clermont-Ferrand, FR
2022 - now
M.S. Université des Antilles, Pointe-à-Pitre, FR
Naomie grew up in Martinique where she studied biology. After working as master’s student on mosquitoes in our lab, she joined the group in Sept 2022 to work on the RACE project (USDA grant) to study the molecular determinants of Ehrlichia ruminantium allowing vector transmission by the tick Amblyomma variegatum. Her work should lead to the development of alternative strategies to control heartwater spreading in non-endemic regions. Naomie loves filling her office with plants, creating creating a pleasant zen atmosphere with her japanese water fountain !
Other group members
2021-now Scientist, Immunology and transcriptomics
Valérie is a scientist in our group since July 2021. She is the WOAH world expert for heartwater disease. She is working mainly in implementing new vaccines against Ehrlichia, developping new diagnostics tools and try to decipher mammalian and insect immune responses in Ehrlichia infection. Valérie comes from Montpellier and enjoys sharing good meals and wines with friends.
2022-now Biotech Engineer, Molecular biology and entomology
Maëlle is a research assistant in our group since September 2022. She is responsible for genetic engineering in Ehrlichia ruminantium and implementing new cellular tools and pathosystems in our lab. Maëlle is originated from Toulouse, famous pink city in Southwest of France. She loves kite surfing and horse riding.
2017-now Lab technician, Molecular biology, serology and entomology
Rosalie is a technician in our group since September 2017. She was involved in the supervision of several students. She works mainly in entomology by maintaining mosquitoes and ticks live collections, working on Ehrlichia development inside the vector tick, collecting ticks from the field as well as maintaining molecular and serological diagnostics capacities on Heartwater. She is responsible for insectarium facilities at CRVC. Rosalie loves singing and dancing traditional Guadeloupean music.
They left us…
2018-2021 PhD student, Microbiology
(Université des Antilles, Pointe-à-Pitre, Guadeloupe, FR)
Stephanie grew up in Guadeloupe and went to College at Université des Antilles, Pointe-à-Pitre, where she obtained a master degree in biology. After working as research assistant, she joined the group first in 2017 to work on the genetic manipulation of Ehrlichia ruminantium in the frame of a patent consolidation (SATT AxLR grant). During her PhD, Stephanie studied the molecular determinants of Anaplasmataceae pathogenicity, particularly through the functional characterization of type IV effectomes. She developed alternative strategies to genetic manipulation for E. ruminantium and her work led to a better understanding of the pathogenesis of this vector-borne intracellular pathogenic bacterium. Stéphanie successfully graduated from the Université des Antilles, Pointe-à-Pitre in December 2021. She is now pursing her own path.
2020 Graduate student, Biologie-Santé
(Université des Antilles, Pointe-à-Pitre, Guadeloupe, FR)
Laetitia graduated from the Université des Antilles, Guadeloupe in 2020, and joined our lab to gain lab research experience in molecular microbioogy. Between January and July 2020, Laetitia worked with Rosalie Aprelon on the characterization of field mosquito populations infected with a Guadeloupean endemic strain of the symbiotic bacterium Wolbachia. Laetitia wants to pursue her academic training by doing a Ph.D on bacterial-host interactions.
2017 Graduate student, IUT Genie Biologique
(Université Claude Bernard, Lyon 1, FR)
Johanna graduated from the Université Claude Bernard, Lyon in 2017, and joined our lab to gain lab research experience and further find a position as lab engineer. Between January and July 2017, Johanna worked with Rosalie Aprelon on the prevalence of Wolbachia in two groups of arthropods disease vectors in Guadeloupe. Johanna is a dedicated scuba diver and loves travelling around the world. She works now at Pau’s hospital as a lab assistant in molecular biology.
2015-2018 PhD student, Computational Biology
(Université des Antilles, Pointe-à-Pitre, Guadeloupe, FR)
Christophe grew up near Dijon in East of France (capital of Burgundy, famous region for its wine, beef, mustard and snails !) and went to college at Université Paul Sabatier, Toulouse where he studied bioinformatics. He joined the group first in 2012, then in 2014, to develop S4TE 1.0 and 2.0 versions. Now, Christophe is studying bacterial genome plasticity and its link with virulence. Christophe is the father of a wonderful little dog named Joy ! With 5 scientific articles and 2 patents, Chris successfully graduated from the Université des Antilles, Pointe-à-Pitre in May 2018. He is now the CEO of a startup in Bioinformatics and Software development. Finger crossed for this new adventure.
2014-2016 Post-doctoral research associate, Computational biology
After great achievements on S. cerevisiae and Xanthomonas spp., Jonathan came in our lab to work on Ehrlichia comparative genomics. Jonathan’s wonderful work led to a better understanding of Ehrlichia genetic secrets.
During his stay in Guadeloupe, Jonathan also perfected his free diving technique to show us astonishing videos… another way to become a world celebrity !
Adela S. Oliva Chavez
2014-2016 Post-doctoral research associate, Molecular Microbiology
Adela defended her Ph.D. on Anaplasma spp. at the University of Minnesota and came in our lab to work on Ehrlichia molecular pathogenesis. She identified critical bacterial genes involved in the infection process of mammalian host cells. Adela won the Young Scientist Award at the TTP8 Conference (24 to 29 August 2014 in Cape Town, South Africa) for her major scientific contribution on the research on Anaplasmataceae .
2011-2015 PhD student, Molecular Microbiology
(Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe, FR)
Amal grew up in Toulouse in South West of France (famous region for its foie gras and rugby team) and went to college at Université Paul Sabatier, Toulouse where she studied plant biology and microbiology. She joined the group in the fall of 2011. Amal worked in identifying effector proteins of E. ruminantium Type IV Secretion System (T4SS) and their role inside the host cell for Ehrlichial invasion. She also characterized the outer membrane proteome of E. ruminantium. Finally, she proved that under specific environmental conditions, a new regulatory protein co-regulated the map and virBD genes, encoding outer membrane proteins and the T4SS, respectively. The aim of her thesis was to better comprehend the intimate nature of E. ruminantium interaction with the host cell. Amal was the responsible of the events committee of the lab and a huge supporter of Toulouse rugby team ! Amal was the first PhD student and successfully graduated from the Université des Antilles et de la Guyane, Pointe-à-Pitre in January 2015 with 5 scientific papers. Her great work paved the way for all the group. We wish her a great career in Science or any domain that will passionate her.
2014 Graduate student, Web development
(Université Paul Sabatier, Toulouse, FR)
After a first successful stay in our lab for the development of S4TE 1.0 software, Christophe came back for the implementation of S4TE 2.0. This new version of S4TE software shows a killer web-based graphical user interface and brand new useful features (e.g. comparative genomics).
2012 Graduate student, Bioinformatics
(Université Paul Sabatier, Toulouse, FR)
Christophe graduated from the Université Paul Sabatier, Toulouse in 2012, and joined our lab to gain bioinformatics research experience and further pursuits to become a engineer in bioinformatics. Between January and June 2012, Christophe sought to develop S4TE (Searching Algorithm for Type IV secretion system Effector proteins ) 1.0 software, a tool for Type IV effectors prediction and genomic context analysis. Christophe is also a cooking super star.
2008-2011 Lab technician, Molecular biology
Catherine goes by “Cathy“ was a technician in our group from September 2009 to August 2010. She was the very first member of the group, and helped to set it up and get things running. She drove the T4SS expression study in E. ruminantium and helped mentoring students. Cathy left our lab to pursue her career at CIRAD, Montpellier. She is now lab technician and responsible for metrology inside AMAP research unit. Cathy brought fashion into the lab.
2010 Graduate student, Molecular biology
(Université Paul Sabatier, Toulouse, FR)
Remi graduated from the Université Paul Sabatier, Toulouse in 2010, and joined our lab to gain lab research experience and further find a position as lab engineer. Between January and July 2010, Remi worked with Cathy on the T4SS expression study in E. ruminantium. Remi is a dedicated football (soccer) supporter and has impressive comics drawing skills.
What we’ve done
Click to download pdf files
(@ indicates corresponding author ; * indicates joint first or senior authors)
37. Gordon J.L., Chavez A.S.O., Martinez D., Vachiery N., and Meyer D.F. (2023) Possible biased virulence attenuation in the Senegal strain of Ehrlichia ruminantium by ntrX gene conversion from an inverted segmental duplication. PLOS ONE, 18(2) : e0266234. https://doi.org/10.1371/journal.pone.0266234
36. Dereeper A., Summo M., and Meyer D.F. (2022) PanExplorer : a web-based tool for exploratory analysis and visualization of bacterial pan-genomes, Bioinformatics, btac504 ; https://doi.org/10.1093/bioinformatics/btac504
35. Pinarello V., Bencurova E., Marcelino I., Gros O., Puech C., Bhide M., Vachiery N., and Meyer D.F.. (2022) Ehrlichia ruminantium uses its transmembrane protein Ape to adhere to host bovine aortic endothelial cells. Peer Community Journal, Volume 2 (2022), article no. e70. doi : 10.24072/pcjournal.189. https://peercommunityjournal.org/articles/10.24072/pcjournal.189/
34. Conjard S., Meyer D. F., Aprelon R., Pages-Martinez N., and Gros O. (2022) Evidence of new strains of Wolbachia symbiont colonising water-striders (Hemiptera : Gerroidea) in the mangrove of the Lesser Antilles. PLOS ONE, Aug 30 ;17(8):e0273668 ; https://doi.org/10.1371/journal.pone.0273668
33. Couvin D., Dereeper A., Meyer D.F., Noroy C., Gaete S., Bhakkan B., Poullet N., Gaspard S., Bezault E., Marcelino I., Pruneau L., Segretier W., Stattner E., Cazenave D., Garnier M., Pot M., Tressières B., Deloumeaux J., Breurec S., Ferdinand S., Gonzalez-Rizzo S., and Reynaud Y. for the KaruBioNet Team. (2021) KaruBioNet : a network and discussion group for a better collaboration and structuring of bioinformatics in Guadeloupe (French West Indies) Bioinformatics Advances, Volume 2, Issue 1, 2022, vbac010 ; https://doi.org/10.1093/bioadv/vbac010
Artistic representation of how pathogenomics can outline virulence factors and their contribution to overall bacterial pathogenesis. The illustration shows the comparison of repertoires of Ehrlichia spp. candidate type IV effectors, prepared using Circos software (Krzywinski et al., Genome Res 2009), and superimposed on a scanning electron microscopy picture (40 000x magnification) of Ehrlichia ruminantium (yellow) adhering to host endothelial cell (purple). Noroy et al. PLOS Comp. Biol. 2021
Image Credit : Images credit : O. Gros, A. Moumene and C. Noroy/Univ. Antilles ; artwork credit : C. Noroy and D. Meyer/Cirad.
32. Noroy C., and Meyer D.F. (2021) The super repertoire of type IV effectors in the pangenome of Ehrlichia spp. provides insights into host-specificity and pathogenesis. PLOS Computational Biology, 17(7) : e1008788. https://doi.org/10.1371/journal.pcbi.1008788
31. Gruel G., Diouf M-B., Abadie C., Chilin-Charles Y., Etter E.M.C., Geffroy M., Herrmann Storck C., Meyer D.F., Pagès N., Pressat G., Teycheney P-Y., Umber M., Vega-Rúa A., Pradel J. (2021) Critical evaluation of cross-sectoral collaborations to inform the implementation of the “One Health” approach in Guadeloupe. Frontiers in Public Health, 9:652079. https://doi.org/10.3389/fpubh.2021.652079
ø. Pinarello V., Bencurova E., Marcelino I., Gros O., PuechC., Bhide M., Vachiery V., and Meyer D.F. (2021) Ehrlichia ruminantium uses its transmembrane protein Ape to adhere to host bovine aortic endothelial cells. bioRxiv, 06.15.447525 ; doi : https://doi.org/10.1101/2021.06.15.447525 Submitted for peer-review
ø. Gordon J.L., Chavez A.S.O., Martinez D., Vachiery N., and Meyer D.F. (2020) Possible biased virulence attenuation in the Senegal strain of Ehrlichia ruminantium by ntrX gene conversion from an inverted segmental duplication. bioRxiv, 11.26.400648 ; doi : https://doi.org/10.1101/2020.11.26.400648 Submitted for peer review
ø. Noroy C., and Meyer D.F. (2020) The super repertoire of type IV effectors in the pangenome of Ehrlichia spp. provides insights into host-specificity and pathogenesis. bioRxiv, 11.07.372862 ; doi : https://doi.org/10.1101/2020.11.07.372862 Submitted for peer review
Interview for the French Press on Resilience and One Health concepts
Little hiatus in science production due to COVID GAME …
30. Noroy C, Lefrançois T, and Meyer DF (2019) Searching Algorithm for Type IV Effector proteins (S4TE) 2.0 : improved tools for type IV effector prediction, analysis and comparison in proteobacteria. PLOS Computational Biology, 15(3) : e1006847. https://doi.org/10.1371/journal.pcbi.1006847
29. Pruneau L, Lebrigand K, Mari B, Lefrançois T, Meyer DF and Vachiery N (2018) Comparative transcriptome profiling of virulent and attenuated Ehrlichia ruminantium strains highlighted strong regulation of map1- and metabolism-related genes. Frontiers in Cellular and Infection Microbiology, 301150 ; doi : https://doi.org/10.3389/fcimb.2018.00153
28. Moumène A, Gonzalez-Rizzo S, Lefrançois T, Vachiéry N and Meyer DF@ (2018) Iron starvation Conditions Upregulate Ehrlichia ruminantium Type IV Secretion System, tr1 Transcription Factor and map1 Genes Family through the Master Regulatory Protein ErxR. Frontiers in Cellular and Infection Microbiology, 7:535. https://doi.org/10.3389/fcimb.2017.00535
ø. Noroy C, Lefrançois T, and Meyer DF@ (2018) Searching Algorithm for Type IV Effector proteins (S4TE) 2.0 : improved tools for type IV effector prediction, analysis and comparison. bioRxiv, 301150 ; doi : https://doi.org/10.1101/301150
27. Noroy, C., and Meyer, D.F.@ (2017) Comparative genomics of the zoonotic pathogen Ehrlichia chaffeensis reveals candidate type IV effectors and putative host cell targets. Frontiers in Cellular and Infection Microbiology, 6:204. https://doi.org/10.3389/fcimb.2016.00204
!!! Featured on Frontiers in Cellular and Infection Microbiology website !!!
26. Cangi, N., Gordon, J., Bournez, L., Pinarello, V., Aprelon, R., Huber, K., Lefrancois, T., Neves, L., and Meyer, D.F. and Vachiéry, N. (2016) Recombination is a major driving force of genetic diversity in the Anaplasmataceae Ehrlichia ruminantium. Frontiers in Cellular and Infection Microbiology, 6:111, http://dx.doi.org/10.3389/fcimb.2016.00111.
25. Tago, D., and Meyer, D.F.@ (2016) Economic Game Theory to Model the Attenuation of Virulence of an Obligate Intracellular Bacterium. Frontiers in Cellular and Infection Microbiology, 6:86, http://dx.doi.org/10.3389/fcimb.2016.00086.
24. Yao, J., Saenkham, P., Levy, J., Ibanez, F., Noroy, C., Mendoza, A., Huot, O., Meyer, D.F., and Tamborindeguy, C. (2016) Interactions ‘Candidatus Liberibacter solanacearum’ – Bactericera cockerelli : haplotype effect on vector fitness and gene expression analyses. Frontiers in Cellular and Infection Microbiology, 6:62, http://dx.doi.org/10.3389/fcimb.2016.00062.
23. Moumene, A., and Meyer, D. F.@. (2016) Ehrlichia ’s molecular tricks to manipulate their host cells. Microbes and Infection, Volume 18, Issue 3, March 2016, Pages 172-179, ISSN 1286-4579, http://dx.doi.org/10.1016/j.micinf.2015.11.001.
22. Villar, M., Ayllón, N., Kocan, K. M., Bonzón-Kulichenko, E., Alberdi, P., Blouin, E.F., Weisheit, S., Mateos-Hernández, L., Cabezas-Cruz, A., Bell-Sakyi, L., Vancová, M., Bílý, T., Meyer, D.F., Sterba, J., Contreras, M., Rudenko, N., Grubhoffer, L., Vázquez J., de la Fuente, J. (2015) Identification and Characterization of Anaplasma phagocytophilum Proteins Involved in Infection of the Tick Vector, Ixodes scapularis. PLOS ONE, 10.1371/journal.pone.0137237.
21. Moumene, A., Marcelino, I., Ventosa, M., Gros, O., Lefrancois, T., Vachiery, N., Meyer, D. F.*@ and and Coehlo AV*. (2015) Proteomic Profiling of the Outer Membrane Fraction of the Obligate Intracellular Bacterial Pathogen Ehrlichia ruminantium. PLOS ONE,10.1371/journal.pone.0116758.
20. Pruneau L, Moumène A, Meyer DF, Marcelino I, Lefrançois T, Vachiéry N. (2014). Understanding Anaplasmataceae pathogenesis using ‘Omics’ approaches. Frontiers in Cellular and Infection Microbiology, doi : 10.3389/fcimb.2014.00086
19. Meyer DF@, Noroy C, Moumène A, Raffaele S, Albina E, Vachiéry N. (2013). Searching algorithm for type IV secretion system effectors 1.0 : a tool for predicting type IV effectors and exploring their genomic context. Nucleic Acids Research, 41 (20) : 9218-9229, first published online August 13, 2013, doi:10.1093/nar/gkt718
18. Marcelino I*, de Almeida AM*, Ventosa M, Pruneau L, Meyer DF, Martinez D, Lefrançois T, Vachiery N and Coelho AV. (2012) Tick-borne diseases in cattle : applications of Proteomics to develop new generation vaccines. Journal of Proteomics, 75 : 4232-4250.
17. Marcelino I*, de Almeida AM*, Brito C, Meyer DF, Barreto M, Sheikboudou C, Franco CF, Martinez D, Lefrançois T, Vachiery N, Carrondo MJT, Coelho AV and Alves PM. (2012) Proteomic analyses of Ehrlichia ruminantium highlight differential expression of MAP1-family proteins. Veterinary Microbiology, 156 (2012) 305–314.
16. Pruneau L*, Emboule L*, Gely P, Marcelino I, Mari B, Pinarello V, Sheikboudou C, Martinez D, Daigle F, Lefrançois T, Meyer DF*@ and Vachiery N*@. (2011) Global gene expression profiling of Ehrlichia ruminantium at different stages of development. FEMS Immunology and Medical Microbiology, 64(1):66-73.
15. Pilet H, Vachiery N, Berrich M, Bouchouicha R, Durand B, Pruneau L, Pinarello V, Saldana A, Carasco-Lacombe C, Lefrançois T, Meyer DF, Martinez D, Boulouis H-J and Haddad N. (2011) A new discriminatory typing technique for the Rickettsiales Ehrlichia ruminantium : Multiple-Locus Variable Number Tandem Repeat Analysis. Journal of Microbiological Methods, 88 (2012) 205–211.
14. Bogdanove AJ, Koebnik R, Lu H, Furutani A, Angiuoli SV, Patil PB, Van Sluys MA, Ryan RP, Meyer DF, Han SW, Aparna G, Rajaram M, Delcher AL, Phillippy AM, Puiu D, Schatz MC, Shumway M, Sommer DD, Trapnell C, Benahmed F, Dimitrov G, Madupu R, Radune D, Sullivan S, Jha G, Ishihara H, Lee SW, Pandey A, Sharma V, Sriariyanun M, Szurek B, Vera-Cruz CM, Dorman KS, Ronald PC, Verdier V, Dow JM, Sonti RV, Tsuge S, Brendel VP, Rabinowicz PD, Leach JE, White FF, Salzberg SL. (2011) Two New Complete Genome Sequences Offer Insight into Host and Tissue Specificity of Plant Pathogenic Xanthomonas spp. Journal of Bacteriology, 193 (19) : 5450-64.
12. Hajri A, Meyer D, Delort F, Guillaumès J, Brin C and Manceau C. (2010) Identification of a genetic lineage within Xanthomonas arboricola pv. juglandis as the causal agent of vertical oozing canker of Persian (English) walnut in France. Plant Pathology, 59 : 1014–1022.
11. Adakal H, Stachurski F, Konkobo M, Zoungrana S, Meyer DF, Pinarello V, Aprelon R, Marcelino I, Alves PM, Martinez D, Lefrancois T, Vachiéry N. (2010) Efficiency of inactivated vaccines against heartwater in Burkina Faso : impact of Ehrlichia ruminantium genetic diversity. Vaccine, 23 ;28(29):4573-80.
10. Ahoussou S, Lancelot R, Sanford B, Porphyre T, Bartlette-Powell P, Compton E, Henry L, Maitland R, Lloyd R, Mattioli R, Chavernac D, Stachurski F, Martinez D, Meyer DF, Vachiery N, Pegram R,Lefrançois T. (2010) Analysis of Amblyomma surveillance data in the Caribbean : lessons for future control programmes. Veterinary Parasitology, 10 ;167(2-4):327-35.
9. Raliniaina M*, Meyer DF*@, Pinarello V, Sheikboudou C, Emboulé L, Kandassamy Y, Adakal H, Stachurski F, Martinez D, Lefrançois T, Vachiéry N@. (2010) Mining the genetic diversity of Ehrlichia ruminantium using map genes family. Veterinary Parasitology, 10 ;167(2-4):187-95.
Viewed from the inside of a fractured rice leaf, cells of the rice pathogenic bacterium Xanthomonas oryzae pv. oryzicola invade through a stoma. Xanthomonas species inject host cells with unusual DNA binding proteins called transcription activator-like (TAL) effectors to up-regulate genes important for infection. Two studies in this issue (pages 1501 and 1509 ; related Perspective, page 1491) decipher TAL effector target specificity and show that new specificities can be engineered. Image : Adam Bogdanove, Damien F. Meyer and Harry Horner/Iowa State University ; false color : Yael Kats/ Science
8. Emboulé L, Daigle F, Meyer DF, Mari B, Pinarello V,Sheikboudou C, Magnone V, Frutos R, Viari A, Barbry P, Martinez D, Lefrançois T, Vachiéry N. (2009) Innovative approach for transcriptomic analysis of obligate intracellular pathogen : selective capture of transcribed sequences of Ehrlichia ruminantium. BMC Molecular Biology, 24 ;10:111. https://doi.org/10.1186/1471-2199-10-111
7. Adakal H, Meyer DF, Carasco-Lacombe C, Pinarello V, Allègre F, Huber K, Stachurski F, Morand S, Martinez D, Lefrançois T, Vachiery N, Frutos R. (2009) MLST scheme of Ehrlichia ruminantium : genomic stasis and recombination in strains from Burkina-Faso. Infection, Genetics and Evolution, 9(6):1320-8. https://doi.org/10.1016/j.meegid.2009.08.003
6. Salzberg SL, Sommer DD, Schatz MC, Phillippy AM, Rabinowicz PD, Tsuge S, Furutani A, Ochiai H, DelcherAL, Kelley D, Madupu R, Puiu D, Radune D, Shumway M, Trapnell C, Aparna G, Jha G, Pandey A, Patil PB, Ishihara H, Meyer DF, Szurek B, Verdier V, Koebnik R, Dow JM, Ryan RP, Hirata H, Tsuyumu S, Won Lee S, Seo YS, Sriariyanum M, Ronald PC, Sonti RV, Van Sluys MA, Leach JE, White FF, Bogdanove AJ. (2008) Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A. BMC Genomics, 1 ;9:204. Erratum in : BMC Genomics. 2008 ;9:534. Seo, Young-Su [added] ; Sriariyanum,Malinee [added]
5. Darsonval A, Darrasse A, Meyer D, Demarty M, Durand K, Bureau C, Manceau C, Jacques MA. (2008) The Type III secretion system of Xanthomonas fuscans subsp. fuscans is involved in the phyllosphere colonization process and in transmission to seeds of susceptible beans. Applied and Environmental Microbiology, 74(9):2669-78.
4. Blanvillain S*, Meyer D*, Boulanger A, Lautier M, Guynet C, Denancé N, Vasse J, Lauber E, Arlat M. (2007) Plant carbohydrate scavenging through TonB-dependent receptors : a feature shared by phytopathogenic and aquatic bacteria. PLOS ONE, 2007 21 ;2(2):e224.
3. Meyer D, Cunnac S, Guéneron M, Declercq C, Van Gijsegem F, Lauber E, Boucher C, Arlat M. (2006) PopF1 and PopF2, two proteins secreted by the type III protein secretion system of Ralstonia solanacearum, are translocators belonging to the HrpF/NopX family. Journal of Bacteriology, 88(13):4903-17.
2. Meyer D, Lauber E, Roby D, Arlat M, Kroj T. (2005) Optimization of pathogenicity assays to study the Arabidopsis thaliana-Xanthomonas campestris pv. campestris pathosystem. Molecular Plant Pathology, 1 ;6(3):327-33.
See also About the Cover, Molecular Plant Pathology 6 (3)
1. Poussier S*, Thoquet P*, Trigalet-Demery D, Barthet S, Meyer D, Arlat M, Trigalet A. (2003) Host plant-dependent phenotypic reversion of Ralstonia solanacearum from non-pathogenic to pathogenic forms via alterations in the phcA gene. Molecular Microbiology, 49(4):991-1003.
4. Gay C, Meyer DF et al. (2018) Heartwater Disease : Potential Worldwide Threats for Livestock.. In Gap Analysis Workshop Report, Agricultural Research Service, Washington, D.C. Invited expert workshop and report, https://go.usa.gov/xVszZ
3. Oura C, Mahase-Gibson A, Stephen C eds. ; contributors Meyer DF et al. (2017) Caribbean Resilience and Prosperity Through One Health. UWI Press. (Trinidad and Tobago). 112pp. ISBN : 978-976-620-293-4. Invited contribution
2. Meyer DF and Bogdanove AJ. (2009) Genomics-driven advances in Xanthomonas biology. In Plant Pathogenic Bacteria : Genomics and Molecular Biology, R.W. Jackson, ed.(Norwich, UK : Horizon Scientific Press), pp. 147-161. Invited book chapter
1. Blanvillain S*, Meyer D, Déjean G, Boulanger A, Lautier M, Guynet C, Denancé N, Vasse J, Lauber E* and Arlat M*. (2008) Plant carbohydrate scavenging through TonB-dependent receptors by the phytopathogenic bacterium Xanthomonas campestris pv. campestris. In Biology of Plant‐Microbe Interactions, Volume 6. M. Lorito, S. L. Woo, and F. Scala, eds. International Society for Molecular Plant-Microbe Interactions, St. Paul, MN.
Meyer Damien, Gordon Jonathan, Vachiéry Nathalie, Martinez Dominique. Live attenuated bacterial strain and its use as a vaccine. 2019. Genève : OMPI, 44 p. N° de dépôt international : PCT/EP2018/075634, N° de brevet international : WO2019057909A1, N° de dépôt européen : 17306235.7, N° de brevet européen : EP3459561
Link to International Patent Collection
Noroy C and Meyer DF. (2016) Searching Algorithm for Type IV secretion system Effector proteins (SATE) version 1.4.
This software has been registered with the "Agence pour la Protection des Programmes (APP)" for version 1.4 under registration number IDDN.FR.001.310023.001.S.P.2012.000.31230, filled March 2016.
Noroy C and Meyer DF. (2012) Searching Algorithm for Type IV secretion system Effector proteins (SATE) version 1.0.
This software has been registered with the "Agence pour la Protection des Programmes (APP)" for version 1.0 under registration number IDDN.FR.001.310023.000.S.P.2012.000.31230, filled June 2012.
I am located in the Caribbean Observatory of the Joint Research Unit "Control of Emerging and Exotic Animal Diseases" on the Duclos campus at CIRAD, Petit-Bourg, Guadeloupe.
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